The effects of gilaburu (Viburnum opulus) juice on experimentally induced Ehrlich ascites tumor in mice

Objective: The aim of study was to investigate anticancer effect of Viburnum opulus (VO) on Ehrlich ascites carcinoma (EAC) bearing mice that treated with different concentrations of VO.

Materials and methods: For tumor transplantation; mice were inoculated with 1 × 10⁶ EAC cells intraperitoneally and than divided into five groups (n = 9). Two hours after inoculation; experimental groups were treated daily with VO extract at doses of 1000 mg/kg, 2000 mg/kg, 4000 mg/kg.

Results: Extracts obtained from gilaburu juice can have hinder effect on tumor cell growth.

Conclusion: As far as we known, this is the first study about in vivo antitumoral activity of VOon Ehrlich ascites tumor model, and consequently VO extract exhibited anticancer activity against EAC-bearing mice.